Silvadene cream 1 uses3/21/2024 ![]() ![]() Topical cream should not be applied to the eye. Topically apply 1% silver sulfadiazine cream after appropriate regimens for burn care have been promptly instituted, including control of shock and pain.Īdministration Topical Administration CreamĪpply 1% cream topically to cleansed, debrided burn wounds under sterile conditions (e.g., using a sterile-gloved hand). Silver Sulfadiazine Dosage and Administration General ![]() Softening action of silver sulfadiazine cream may aid in eschar removal and preparation of wound for grafting. Unlike mafenide, a carbonic anhydrase inhibitor, silver sulfadiazine does not alter acid-base balance and does not have a limited duration of therapy and area of topical application. Mafenide appears to penetrate burn eschar better than silver sulfadiazine and may be more effective in minimizing the growth of bacteria and early treatment of wound sepsis. Silver sulfadiazine cream is used topically as adjunct therapy to prevent and treat wound sepsis in second- and third-degree burns after resuscitative measures (e.g., control of shock and pain, correction of electrolyte imbalance) have been instituted.Ĭontrol of bacterial growth may prevent conversion of deep, second-degree (partial-thickness) wounds to third-degree (full-thickness) wounds by sepsis.Ĭoncomitant administration of appropriate systemic anti-infective agents may be necessary if infection present or suspected.Īlthough controlled, comparative studies are lacking, silver sulfadiazine and mafenide are considered by many clinicians to be among the topical anti-infective agents of choice in burn patients. Uses for Silver Sulfadiazine Prevention and Treatment of Burn Infections Sulfonamide synthetic anti-infective agent. Drug class: Local Anti-infectives, Miscellaneous
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